翻訳と辞書
Words near each other
・ Mir Yusof-e Olya
・ Mir Yusof-e Sofla
・ Mir Zafar Ali
・ Mir, Belarus
・ Mir, Iran
・ Mir-1
・ Mir-1 microRNA precursor family
・ Mir-10 microRNA precursor family
・ Mir-101 microRNA precursor family
・ Mir-103/107 microRNA precursor
・ Mir-11 microRNA precursor family
・ MiR-122
・ Mir-124 microRNA precursor family
・ Mir-126
・ Mir-127
Mir-129 microRNA precursor family
・ Mir-130 microRNA precursor family
・ MiR-132
・ Mir-133 microRNA precursor family
・ MiR-134
・ Mir-135 microRNA precursor family
・ Mir-137
・ MiR-138
・ Mir-14 microRNA precursor family
・ Mir-143
・ MiR-144
・ Mir-145
・ MiR-146
・ Mir-148/mir-152 microRNA precursor family
・ Mir-15 microRNA precursor family


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Mir-129 microRNA precursor family : ウィキペディア英語版
Mir-129 microRNA precursor family

The miR-129 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. This microRNA was first experimentally characterised in mouse and homologues have since been discovered in several other species, such as humans, rats and zebrafish. The mature sequence is excised by the Dicer enzyme from the 5' arm of the hairpin. It was elucidated by Calin ''et al.'' that miR-129-1 is located in a fragile site region of the human genome near a specific site, FRA7H in chromosome 7q32, which is a site commonly deleted in many cancers. miR-129-2 is located in 11p11.2.
==Expression Patterns==
miR-129 seems to have a tissue specific expression pattern localised to the brain in normal humans. This finding was identified initially by microarray experimentation with mouse tissue (and more specifically to the cerebellum)〔 which was subsequently validated by the expression profiling in human tissue. However, expression in normal brain tissue was found to be relatively low and different profiling experimentation methodologies produced differing results. These differences and the low levels of detection may be attributed to the size and complexity of the human brain and the fact that specific regions of the brain were not individually tested.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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